I heard the word carcinoma.

There are four types of tissues found in the human body connective, muscle, nervous, and epithelial.

Breast density refers to the relative amount of fat pictured here in yellow versus connective and epithelial tissues pictured in pink.

And so, please consider this a work in progress, but I'd like to tell you today a story about a very rare cancer called midline carcinoma, about the undruggable protein target that causes this cancer, called BRD4, and about a molecule developed at my lab at Dana Farber Cancer Institute, called JQ1, which we affectionately named for Jun Qi, the chemist that made this molecule.