And what we do is we grow extracellular matrix from pigs.

We have made a lot of discoveries, we have shown that extracellular matrix talks to chromatin.

We submitted over 300 samples of mushrooms that were boiled in hot water, and mycelium harvesting these extracellular metabolites.

So I said, extracellular matrix, which is this stuff called ECM, signals and actually tells the cells what to do.

But before we do that, I'd like you to think that at any given time when you're sitting there, in your 70 trillion cells, the extracellular matrix signaling to your nucleus, the nucleus is signaling to your extracellular matrix and this is how your balance is kept and restored.

We have shown that there's little pieces of DNA on the specific genes of the mammary gland that actually respond to extracellular matrix.

But when the bacteria grow and double and they're all participating in making these molecules, the molecule the extracellular amount of that molecule increases in proportion to cell number.

We found some gooey material that had the right extracellular matrix in it, we put the cells in it, and lo and behold, in about four days, they got reorganized and on the right, is what we can make in culture.

In order to do that, however, we needed to have a method of distinguishing normal from malignant, and on the left is the single normal cell, human breast, put in three dimensional gooey gel that has extracellular matrix, it makes all these beautiful structures.

We should be able to be dealing with these things at this level, and these conclusions say that growth and malignant behavior is regulated at the level of tissue organization and that the tissue organization is dependent on the extracellular matrix and the microenvironment.