Insulin is produced in the Pancreas, what happens if the pancreas is not producing insulin properly? so.. no insulin.

That syringe contains insulin.

like the insulin pathway.

I had become insulin resistant.

Your insulin is in here.

The insulin was making her fat.

This is a typical insulin injection.

So this right here is insulin.

More importantly, I don't have insulin resistance.

Well, it could be insulin or heroin.

Just like with Type 1, insulin can also be injected into the bloodstream. Now, you might say Wait! I already have insulin here... why would I add MORE insulin? .

So now, when insulin says to a cell,

Now you've all heard of at least insulin.

like stents and insulin pumps for the diabetic.

So, once again let me draw some glucose floating by... some insulin receptors on the cell, and let's have some insulin.

So, if you add enough insulin, there may be enough to bind with the insulin receptors and cause some glucose absorption.

But insulin accelerates the conversion of calories into fat.

Insulin is required for life, it's an essential hormone.

I'll start with insulin, diabetes medication in the U.S.

How many people are taking their insulin every day?

For insulin right here, this is 50 amino acids.

Now failure to produce enough insulin is incompatible with life.

This is a pen, it's called an insulin pen, preloaded.

I'll probably go into insulin shock. But it's worth it.

And insulin resistance, as its name suggests, is when your cells get increasingly resistant to the effect of insulin trying to do its job.

So let me label all of these, this is glucose and it needs insulin so let me draw insulin here as a magenta molecule.

The only problem here, and it's a big one, is that there is no insulin in the bloodstream. So, over here we can inject insulin.

Now, most researchers believe obesity is the cause of insulin resistance.

What if obesity isn't the cause of insulin resistance at all?

Yes, we started an IV. D50 with 20 units of insulin.

Your pancreas makes insulin to bring it back down, which is good.

Once you're insulin resistant, you're on your way to getting diabetes, which is what happens when your pancreas can't keep up with the resistance and make enough insulin.

like the insulin and the IGF hormones and the TOR pathway, they're essential.

Whatever killed those people on that plane got onboard through his insulin pen.

Remember, just because the cells are desensitized, it doesn't mean they won't bind with insulin, it just means it will take MORE insulin to uptake the same amount of glucose.

When we become insulin resistant, the homeostasis in that balance deviates from this state.

So what if we're fighting the wrong war, fighting obesity rather than insulin resistance?

It's a gross oversimplification, but let me say this is the gene for insulin.

We know that 30 million obese Americans in the United States don't have insulin resistance.

Now, one way of managing Type 1 diabetes is to inject insulin into the bloodstream.

So for many of us, about 75 million Americans, the appropriate response to insulin resistance may actually be to store it as fat, not the reverse, getting insulin resistance in response to getting fat.

Logically, then, if you want to treat insulin resistance, you get people to lose weight, right?

And just to be able to relate this to the DNA, this right here is insulin.

So let's say the 150 base pairs that coded for insulin, these make up a gene.

So our Pancreas is producing insulin and putting it into our bloodstream, so it's there to be used. but a situation can arise where the receptors are not working properly, and they have been desensitized to insulin.