I heard the word carcinoma.

The normal example, let's take the human mammary gland.

You all remember, dolly, it came from a single mammary cell.

Now if you take the mammary gland and spread it and take the fat away, on a dish it looks like that.

We have shown that there's little pieces of DNA on the specific genes of the mammary gland that actually respond to extracellular matrix.

Of those that don't abort, atrazine causes impaired mammary, or breast, development in the exposed daughters in utero, so that their breast don't develop properly.

So, we decided that what we like to do is take just a bit of that mammary gland, which is called an acinus, where there are all these little things inside the breast where the milk goes, and the end of the nipple comes through that little tube when the baby sucks.

And so, please consider this a work in progress, but I'd like to tell you today a story about a very rare cancer called midline carcinoma, about the undruggable protein target that causes this cancer, called BRD4, and about a molecule developed at my lab at Dana Farber Cancer Institute, called JQ1, which we affectionately named for Jun Qi, the chemist that made this molecule.

So, we made a section of the mammary gland of the mouse, and all those lovely acini are there, every one of those with the red around them are an acinus, and we said okay, we are going to try and make this, and I said, maybe that red stuff around the acinus that people think there's just a structural scaffold, maybe it has information, maybe it tells the cells what to do, maybe it tells the nucleus what to do.