I'd gained a lot of weight and developed something called metabolic syndrome.

Can we do anything useful with this capacity to control metabolic flexibility?

So, I'm interested in the use of metabolic materials for the practice of architecture.

Positron Emission Tomography uses a radioactive tracer to visualize metabolic activity within the human body.

That actually for a given body mass of a primate the metabolic rate was static.

But I knew that there were examples of creatures, also mammals, that do reduce their metabolic rate such as ground squirrels and bears, they reduce their metabolic rate in the wintertime when they hibernate.

So when we think about scaling up metabolic materials, we can start thinking about ecological interventions

So, all of these things greater metabolic demands, reduced reproductive success, changes in respiration and metabolism.

In addition to the virus, I'm injecting you with a metabolic catalyst to accelerate your immune response.

It's not a disease caused by some metabolic problem, it's a disease of the immune system making mistakes.

Anger creates a metabolic reaction in the body, which stresses it out and heats up our internal temperature.

Two mg of oral triazolam... every seven hours induces a safe sleep state and a minimal metabolic rate.

We have, from the time we are slapped on the butt until we take our last dying breath that's when we're newborn to when we're dead we cannot reduce our metabolic rate below what's called a standard, or basal metabolic rate.

Secondly, these metabolic materials have some of the properties of living systems, which means they can perform in similar ways.

If metabolic people (Laughter) see their own skeleton models and find a lot of fat, then they'll start a diet.

So therefore, they must have something within their DNA that ables them to deal with the metabolic stresses, particularly of flight.

So, in summary, I'm generating metabolic materials as a counterpoise to Victorian technologies, and building architectures from a bottom up approach.

I'm not suggesting that obesity is benign, but what I am suggesting is it may be the lesser of two metabolic evils.

So one of the things we're seeing is organisms are having to spend more metabolic energy to build and maintain their shells.

If obesity is nothing more than a proxy for metabolic illness, what good does it do us to punish those with the proxy?

It's too cold he can't keep his metabolic fires going, and, you see, there's no more red here his brain is quieting down.

Now, what you do is, you get inside the microbe, you change its metabolic pathways, and you end up with a living chemical factory.

What if being obese is just a metabolic response to something much more threatening, an underlying epidemic, the one we ought to be worried about?

But most important in this, the exponent, the analog to that three quarters for the metabolic rate, is bigger than one it's about 1.15 to 1.2.

What is plotted here is metabolic rate how much energy you need per day to stay alive versus your weight, your mass, for all of us bunch of organisms.

So just through self assembly, mixing things together in the lab, we can come up with, say, a metabolic surface with some informational molecules attached inside of this membrane body, right?

Well, typically, in mammals there is a relationship between body size, metabolic rate, and how long you can live for, and you can predict how long a mammal can live for given its body size.

its cells respond far more vigorously, and their metabolic requirement increases, and so more blood is channeled to that part of the brain, and this change in blood flow can be captured by these scanners.

Conversely, we know that six million lean people in the United States are insulin resistant, and by the way, they appear to be at even greater risk for those metabolic diseases I mentioned a moment ago than their obese counterparts.

As you can see here on this graph, in blue, these are all other mammals, but bats can live up to nine times longer than expected despite having a really, really high metabolic rate, and the question is, how can they do that?

You'll have greater insight, you'll have faster reflexes, reduced risk of injury, you'll optimize your metabolic fitness and your appetite, enhance your immunity, decrease your risk of infection, reduce your risk of diseases like diabetes, and stroke, and cancer and heart disease.

When we look at its metabolic map, it's relatively simple compared to ours trust me, this is simple but when we look at all the genes that we can knock out one at a time, it's very unlikely that this would yield a living cell.

Might there be some agent that is in us, something that we make ourselves, that we might be able to regulate our own metabolic flexibility in such a way as to be able to survive when we got extremely cold, and might otherwise pass away?

And a variety of other studies have shown that the microbial community that lives in and on us helps in development of the immune system, helps in fighting off pathogens, helps in our metabolism, and determining our metabolic rate, probably determines our odor, and may even shape our behavior in a variety of ways.

But we've also discovered, when it comes to plants, in plants, as much as we understand and are starting to understand their genomes, it is the ecosystem around them, it is the microbes that live in their root systems, that have just as much impact on the character of those plants as the metabolic pathways of the plants themselves.

And I want to say that I think we're on the path of understanding metabolic flexibility in a fundamental way, and that in the not too distant future, an EMT might give an injection of hydrogen sulfide, or some related compound, to a person suffering severe injuries, and that person might de animate a bit, they might become a little more immortal.