You see this receptor? It's called an AMP receptor.

The progesterone, testosterone, estradiol. It's all in the logs.

Look at this kind, the NR receptor, also called the NMDA receptor.

It's very interesting. Very undemocratic receptor.

The receptor isn't working as well.

Researchers Identify New Receptor Complex in Brain

The daf 2 hormone receptor is very similar to the receptor for the hormone insulin and IGF 1.

Don't have an HER 2 receptor? Don't take Receptin.

And the daf 2 gene encodes a hormone receptor.

Each molecule fits into its partner receptor and no other.

I analyzed your blood isolating the receptor compounds and the proteinbased catalyst.

So a woman, age 37, presents with stage 2 estrogen receptor positive breast cancer.

Okay, so what is the daf 2 receptor telling the inside of the cell?

So that means that the normal function of this hormone receptor is to speed up aging.

So in a daf 2 mutant you see that I have the X drawn here through the receptor.

When rat pups are born, their glucacorticoid receptor gene is surrounded by a number of these silencing Epigenetic marks.

So, the more receptor that the rat has in this region of the brain, the better it will handle stress.

This allows the glucacoid receptor gene to turn back on, and it stays on in those pups' brains throughout their lives.

And the bacteria also have a receptor on their cell surface that fits like a lock and key with that molecule.

Whenever a flash of light hits the receptor, the pore opens, an electrical current is switched on, and the neuron fires electrical impulses.

And when they were subject to the plague, most people didn't survive, but those who survived had a mutation on the CCR5 receptor.

Rats contain a gene called the glucacorticoid receptor and this gene can be expressed, or read, in a certain region of the rat's brain.

So what you see in the picture there is a cell with a hormone receptor in red punching through the edge of the cell.

So, they have a second enzyme that makes a second signal and it has its own receptor, and this molecule is the trade language of bacteria.

One little software program, called the fat insulin receptor gene, basically says, Hold onto every calorie, because the next hunting season may not work out so well.

Well when the daf 2 receptor is active, then it triggers a series of events that prevent FOXO from getting into the nucleus where the DNA is.

And can we utilize can we take this property, this compound, this receptor, whatever it is that's controlling these anti tumor properties and apply it to cancer therapy in general?

I just told you that, if you make a mutation in the daf 2 gene cell, that you get a receptor that doesn't work as well the animal lives longer.

If a rat mother ignores her pups (Laughter) that glucacoid receptor gene will maintain those silencing Epigenetic marks, they won't go away, and they'll stay in those pups' brains throughout their lives.

What that means is if you can tickle the fancy of this NMDA receptor, you'll put in more of these ordinary AMPA receptors into the synapse, and then the synapse will become stronger.

And what they found was that people who lived to 90 or 100 were more likely to have daf 2 mutations that is, changes in the gene that encodes the receptor for IGF 1.

So after we made our discoveries with little C. elegans, people who worked on other kinds of animals started asking, if we made the same daf 2 mutation, the hormone receptor mutation, in other animals, will they live longer?

They have discovered pathways that create flavors, although it's very important to understand that those compounds that it's cranking out have to match a receptor in our genome, in our tongue, for us to understand and interpret those flavors.

When the molecule increases to a certain amount which says something about the number of cells it locks down into that receptor and information comes into the cells that tells the cells to turn on this collective behavior of making light.

There are studies that have shown that interactions between a rat mother and her pups during the first week of their life can have long term consequences for how much glucacorticoid receptor those pups will grow up to have in their brains and therefore how well they will handle stress.