This is what happened to the children of the Dutch Hunger Winter.

Why would someone leave their home to go for a brisk walk in a toxic neighborhood?

I'm on my third generation of kids that they're getting bigger.

An obese man.

People are dying from curable diseases in South Central, Los Angeles.

And in one generation, for example,

So if you put these physiological processes to work,

I think he's 1 100 pounds of baby fat.

He is overweight.

A fat boy, too !

What'd I just watch? (men singing dramatic tune in Japanese) (kid screams) Aah!

The reason that we know that the ABC campaign was effective in Uganda is we have good data on prevalence over time.

On the far left, you see the purple line.

People are dying from curable diseases in South Central Los Angeles.

And the bottom curve is the weight of a normal mouse.

Vicki. Victoria was an overweight Queen.

But this leaves us with a big gap in our knowledge.

In addition, because obesity is not a unicentric epidemic, there's not a Patient Zero of the obesity epidemic if we find that guy, there was a spread of obesity out from him it's a multicentric epidemic.

I suffer from obesity.

And the patients started drifting in.

India has equally horrible health problems of the higher state of cardiac issue, the higher state of diabetes, the higher state of obesity.

But now I want to actually also question that.

We are a very sick nation, with diabetes, heart disease, cancer, and childhood obesity, all on the rapid increase.

And in one generation, they're going from hunger, and all of the detrimental health effects of hunger, to obesity and things like diabetes and heart disease in one generation.

Well, he's right, but he didn't say to me, well, you have pre obesity or you have pre diabetes, or anything like that.

Discovery consists of seeing what everyone has seen, and thinking what no one has thought.

So this is another way to see this.

I was fat as a boy.

So my first topic with respect to this, was not death, but obesity.

Interestingly, one of those birth defects has seen a 200 percent increase in the U.S.

But in my world, it's called reduced obesity and diabetes.

Futureless language speakers are 20 to 24 percent less likely to be smoking at any given point in time compared to identical families, and they're going to be 13 to 17 percent less likely to be obese by the time they retire, and they're going to report being 21 percent more likely to have used a condom in their last sexual encounter.

But obviously the bigger problem that we all know about is obesity, and it's dramatic.

He's a fat boy.

Americans have been told to eat less fat, the percent of calories from fat is down,

Maybe we should be asking ourselves, is it possible that insulin resistance causes weight gain and the diseases associated with obesity, at least in most people?

And the way that I'm going to do that is,

But what if we have it backwards?

The numbers are pretty crazy.

But that actually doesn't mean at all that if we gave people more exports, more trade, that that would increase prevalence.

That happens in less than 2 of our missions.

Can we shrink fat by cutting off its blood supply?

So what if we're fighting the wrong war, fighting obesity rather than insulin resistance?

Rooney. Congrats.

Are you packing it on?