She wants to lose weight because she is overweight.

Now, most researchers believe obesity is the cause of insulin resistance.

Logically, then, if you want to treat insulin resistance, you get people to lose weight, right?

But in my world, it's called reduced obesity and diabetes.

I suffer from obesity.

Americans have been told to eat less fat, the percent of calories from fat is down,

On the far left, you see the purple line.

But obviously the bigger problem that we all know about is obesity, and it's dramatic.

An obese man.

So my first topic with respect to this, was not death, but obesity.

He is overweight.

A fat boy, too !

In addition, because obesity is not a unicentric epidemic, there's not a Patient Zero of the obesity epidemic if we find that guy, there was a spread of obesity out from him it's a multicentric epidemic.

So what if we're fighting the wrong war, fighting obesity rather than insulin resistance?

What'd I just watch? (men singing dramatic tune in Japanese) (kid screams) Aah!

I think he's 1 100 pounds of baby fat.

Vicki. Victoria was an overweight Queen.

And if you're above 25, let's say 25 to 30, then you're in the overweight range.

And the patients started drifting in.

This is what happened to the children of the Dutch Hunger Winter.

I was fat as a boy.

Maybe we should be asking ourselves, is it possible that insulin resistance causes weight gain and the diseases associated with obesity, at least in most people?

Are you packing it on?

And the bottom curve is the weight of a normal mouse.

I'm sorry, old buddy, but it looks like you're stuck... cleaning up the fat man.

He's a fat boy.

People are dying from curable diseases in South Central Los Angeles.

We put in the value of n, and we call it again.

Big, but five years old.

Decreases the components reference counter.

And underlying these questions,

So this approach that we're taking for cancer prevention may also have an application for obesity.

This here shows, on the Y axis, the increase in the probability that a person is obese given that a social contact of theirs is obese and, on the X axis, the degrees of separation between the two people.

I put my food waste into this dehydrating, desiccating macerator turns food into an inner material, which I can store and then compost later.

PCBs, DDT cross the placenta and effectively determine the likelihood of developing breast cancer and obesity and diabetes already when the baby's in the womb.

Can we shrink fat by cutting off its blood supply?

Do we remove a star?

I did this and lost 40 pounds, weirdly while exercising less.

And the next bar over, the red line, says if your friend's friends are obese, your risk of obesity is 25 percent higher.

Now how about other exponentials?

Let's look at some suggestive facts.

What with having no exercise and being overweight, he had a heart attack.

And just to show you this, this is from the CDC.

So if you put these physiological processes to work,

I mean, this is a scary slide, not to take an aside, but it looks at obesity in the world.