I heard the word carcinoma.

The prognosis is poor for progressing renal cell cancer.

I'm afraid your daughter shows signs of renal failure.

I even knew the differential diagnosis in how to classify renal tubular acidosis.

What you die of is increasing organ failure, with your respiratory, cardiac, renal, whatever organs packing up.

And even skin infection, which we originally thought wasn't that big a problem, mild skin infections naught to five give you a greatly increased chance of renal failure, needing dialysis at age 40.

doctor, we have renal failure. we should have shut his kidneys down when he first came in. the power drain is too much. we're losing systolic pressure. what does that mean? anita, michael, wait outside. wilson, i think i have a right to be here, and i'd like to kn... outside now.

And so, please consider this a work in progress, but I'd like to tell you today a story about a very rare cancer called midline carcinoma, about the undruggable protein target that causes this cancer, called BRD4, and about a molecule developed at my lab at Dana Farber Cancer Institute, called JQ1, which we affectionately named for Jun Qi, the chemist that made this molecule.